Anti-RCAN1 antibody

Catalog Number:

A001035752STJ

Mfr. No.:

STJ27279

Price:

$297

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Overview
- The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 60-245 of human RCAN1 (NP_004405. 3).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Calcipressin-1; Adapt78; Down Syndrome Critical Region Protein 1; Myocyte-Enriched Calcineurin-Interacting Protein 1; Mcip1; Regulator Of Calcineurin 1 (Gene ID:1827; UniProt:P53805)
  
  * For research use only