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Overview
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This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
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Overview
Immunohistochemistry of paraffin-embedded human gastric cancer using RBBP7 antibody (STJ115417) at dilution of 1:100 (40x lens).
Chromatin immunoprecipitation analysis of extracts of 293T cells, using RBBP7 antibody (STJ115417) and rabbit IgG. The amount of immunoprecipitated DNA was checked by quantitative PCR. Histogram was constructed by the ratios of the immunoprecipitated DNA to the input.
Western blot analysis of extracts of various cell lines, using RBBP7 antibody (STJ115417) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.
Anti-RBBP7 antibody
Anti-RBBP7 antibody
Catalog Number:
A001022312STJ
Mfr. No.:
STJ115417
Price:
$297
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