Anti-RASGRF1 antibody

Anti-RASGRF1 antibody

Catalog Number:
A001037074STJ
Mfr. No.:
STJ29044
Price:
$297
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      • Overview
        • The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

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      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse
          Immunogen
          Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RASGRF1 (NP_001139120. 1).
          Purification
          Affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
          Storage
          Store at -20°C and avoid freeze-thaw cycles.
          Regulatory Status
          RUO
          Antigen
          Ras-Specific Guanine Nucleotide-Releasing Factor 1; Ras-Grf1; Guanine Nucleotide-Releasing Protein; Gnrp; Ras-Specific Nucleotide Exchange Factor Cdc25 (Gene ID:5923; UniProt:Q13972)

          * For research use only

      • Applications
        • Application
          WB; IHC; IF
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:50-1:200
          IF 1:50-1:100

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