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Overview
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The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
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Overview
Immunohistochemistry of paraffin-embedded rat heart using PRNP Antibody (STJ25153) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human smooth muscle using PRNP Antibody (STJ25153) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of mouse brain, using PRNP antibody (STJ25153) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 5s.
Anti-PRNP antibody
Anti-PRNP antibody
Catalog Number:
A001034778STJ
Mfr. No.:
STJ25153
Price:
$297
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