Name: Anti-POU5F1 antibody
Price: 331.00 USD

Overview
- Transcription factors containing the POU homeo domain have been shown to be important regulators of tissue‐specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. POU domain proteins contain a bipartite DNA‐binding domain divided by a flexible linker that enables them to adopt various monomer configurations on DNA. The versatility of POU protein operation is additionally conferred at the dimerization level. Oct‐3 (also known as Oct‐4) is a mammalian POU transcription factor expressed by early embryo cells and germ cells. Oct‐4 is essential for the identity of the pluripotential founder cell population in the mammalian embryo. A critical amount of Oct‐4 is required to sustain stem‐cell self‐renewal, and up or down regulation induce divergent developmental programs. Two isoforms of Oct‐3, termed Oct‐3A and Oct‐3B, are generated by alternative splicing. The gene which encodes Oct‐3/4 maps to human chromosome 6p21.3. Oct‐4 (C‐10) is recommended for detection of Oct‐3A (Oct‐4) and Oct‐3B of mouse, rat and human origin by Western Blotting, immunoprecipitation, immunofluorescence, and paraffin immunohistochemistry.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2b kappa
  
  Reactivity
  
  human
  
  Clone
  
  C‐10
  
  Immunogen
  
  Amino acids 1‐134 of OCT‐4 of human origin
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only