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Overview
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This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
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Overview
Immunofluorescence analysis of U2OS cells using PNP antibody (STJ115967). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using PNP antibody (STJ115967) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 60s.
Anti-PNP antibody
Anti-PNP antibody
Catalog Number:
A001022844STJ
Mfr. No.:
STJ115967
Price:
$297
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