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Overview
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The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate, and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of fructose-2, 6-bisphosphate. This protein regulates fructose-2, 6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2, 6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.
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- Properties
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Overview
Western blot analysis of extracts of HeLa cells, using Phospho-PFKFB2-S483 antibody (STJ117882) at 1:2000 dilution.HeLa cells were treated by IGF-1 (50 ng/ml) at 37°C for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 5s.
Anti-Phospho-PFKFB2-(S483) antibody
Anti-Phospho-PFKFB2-(S483) antibody
Catalog Number:
A001024723STJ
Mfr. No.:
STJ117882
Price:
$295
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