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Overview
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The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate to 1D-myo-inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
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- Properties
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Overview
Western blot analysis of extracts of Raji cells, using Phospho-PLCG2-Y759 pAb (STJ117883) at 1:2000 dilution or PLCG2 antibody (STJ25024).Raji cells were treated by Pervanadate (1 mM) at 37°C for 30 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit.Exposure time: 1s.
Western blot analysis of extracts of Raji cells, using Phospho-PLCG2-Y759 antibody (STJ117883) at 1:2000 dilution or PLCG2 antibody (STJ25024). Raji cells were treated by Pervanadate (1 mM) at 37°C for 30 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit.Exposure time: 1s.
Anti-Phospho-PLCG2-(Y759) antibody
Anti-Phospho-PLCG2-(Y759) antibody
Catalog Number:
A001024724STJ
Mfr. No.:
STJ117883
Price:
$295
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