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Overview
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VE-Cadherin is a protein encoded by the CDH5 gene which is approximately 87, 5 kDa. VE-Cadherin is localised to the cell junction and cell membrane. It is involved in cell junction organization, blood-brain barrier and immune cell transmigration, ERK signalling and RET signalling. It is a calcium-dependent cell-cell adhesion molecule that is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. It functions by allowing cells the ability to adhere in a homophilic manner and plays a role in endothelial adherent junction assembly and maintenance. VE-Cadherin is expressed in the heart, nervous system, bone marrow, muscle and lung. Mutations in the CDH5 gene may result in periapical granuloma. STJ97306 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of VE-Cadherin protein.
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