Name: Anti-ERK1 antibody
Price: 224.00 USD

Overview
- ERK1 is a protein encoded by the MAPK1 gene which is approximately 41, 3 kDa. ERK1 is localised to the cytoplasm, cytoskeleton ad nucleus. It is involved in RET signalling, activated TLR4 signalling, the IL-2 pathway, regulation of lipid metabolism and insulin signalling-generic cascades. This protein falls under the MAP kinase family and acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. Upon its activation, it translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. ERK1 is expressed in the cells of the nervous system, blood, lung, liver and skin. Mutations in the MAPK1 gene may result in small intestine neuroendocrine neoplasm. STJ97780 was developed from clone 5E9 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of MAPK3.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human; rat; mouse
  
  Clone
  
  5E9
  
  Immunogen
  
  Recombinant peptide derived from ERK1
  
  Purification
  
  The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  
  Storage
  
  Store at -20°C and avoid repeat freeze-thaw cycles.
  
  Concentration
  
  1 mg/ml
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Mitogen-Activated Protein Kinase 3; Map Kinase 3; Mapk 3; Ert2; Extracellular Signal-Regulated Kinase 1; Erk-1; Insulin-Stimulated Map2 Kinase; Map Kinase Isoform P44; P44-Mapk; Microtubule-Associated Protein 2 Kinase; P44-Erk1 (Gene ID:5594; UniProt:P27361)
  
  * For research use only