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Overview
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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
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Overview
Immunohistochemistry of paraffin-embedded mouse liver using PCSK9 antibody (STJ110170) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat kidney using PCSK9 antibody (STJ110170) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using PCSK9 antibody (STJ110170) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of SW480 cells, using PCSK9 Antibody (STJ110170) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 30s.
Anti-PCSK9 antibody
Anti-PCSK9 antibody
Catalog Number:
A001017022STJ
Mfr. No.:
STJ110170
Price:
$297
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