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Overview
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This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded mouse brain using OGG1 antibody (STJ24860) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using OGG1 antibody (STJ24860) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-OGG1 antibody
Anti-OGG1 antibody
Catalog Number:
A001034599STJ
Mfr. No.:
STJ24860
Price:
$297
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