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Overview
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This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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- Properties
- Applications
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Overview
Immunofluorescence analysis of U2OS cells using OGDH antibody (STJ28474). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat ovary using OGDH antibody (STJ28474) at dilution of 1:100 (20x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using OGDH antibody (STJ28474) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using OGDH antibody (STJ28474) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit._Exposure time: 90s.
Anti-OGDH antibody
Anti-OGDH antibody
Catalog Number:
A001036570STJ
Mfr. No.:
STJ28474
Price:
$297
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