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Overview
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This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
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- Properties
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Overview
Immunofluorescence analysis of L929 cells using NOTCH4 Rabbit pAb (STJ110601) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of Mouse kidney, using NOTCH4 antibody (STJ110601) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 1s.
Anti-NOTCH4 antibody
Anti-NOTCH4 antibody
Catalog Number:
A001017360STJ
Mfr. No.:
STJ110601
Price:
$297
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