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Overview
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The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene.
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Overview
Immunohistochemistry of paraffin-embedded human stomach using PTTG1 antibody (STJ110605) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung cancer using PTTG1 antibody (STJ110605) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human liver using PTTG1 antibody (STJ110605) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using PTTG1 antibody (STJ110605) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-PTTG1 antibody
Anti-PTTG1 antibody
Catalog Number:
A001017364STJ
Mfr. No.:
STJ110605
Price:
$297
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