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Overview
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Recognizes a 125 kD extracellular macrophage membrane molecule, highly restricted tomature macrophage subpopulations residing in tissue. This murine F4/80 glycoprotein contains seven-transmembrane (TM7) regions, which anchor the protein in the cell membrane, and thereby showssimilarity in this region to G-protein-coupled receptors. The F4/80 molecule shares overall structuralhomology to other members of the epidermal growth factor (EGF)-TM7 family. The antigen is detectedon tissue fixed macrophages in all organs tested so far (spleen, lymph nodes, thymus, liver, skin). It isalso present on Langerhans cells in the skin and Kupffer cells in the liver. It is absent on granulocytes, lymphocytes and trombocytes. The expression of F4/80 increases upon maturation of macrophageprecursors in bone marrow and blood as well as in ontogeny.is the only macrophage marker that is able to distinguish non-destructive from destructiveinflammation processes in the pancreas. Furthermore it is a unique histological marker of theprogression from peri-insulitis to beta-cell destruction and diabetes in a mouse diabetes model.
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