Name: Anti-MDM2 antibody
Price: 334.00 USD

Overview
- p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA‐damaging agents. The MDM2 (murine double minute‐2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53‐mediated transactivation of co‐transfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wide type p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression (gene amplification) represents at least one mechanism by which p53 function can be abrogated during tumorigenesis. MDM2 is useful in differentiating well‐ differentiated/dedifferentiated liposarcoma from other types of sarcomas.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1 kappa
  
  Reactivity
  
  human
  
  Clone
  
  SMP14
  
  Immunogen
  
  Amino acids 154‐167 of MDM2 of human origin
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  E3 Ubiquitin-Protein Ligase Mdm2; Double Minute 2 Protein; Hdm2; Oncoprotein Mdm2; Ring-Type E3 Ubiquitin Transferase Mdm2; P53-Binding Protein Mdm2 (Gene ID:4193; UniProt:Q00987)
  
  * For research use only