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Overview
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This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants.
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Overview
Immunohistochemistry of paraffin-embedded mouse lung using LRP5 antibody (STJ29785) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human liver using LRP5 antibody (STJ29785) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded human prostate using LRP5 antibody (STJ29785) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using LRP5 antibody (STJ29785) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-LRP5 antibody
Anti-LRP5 antibody
Catalog Number:
A001037718STJ
Mfr. No.:
STJ29785
Price:
$297
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