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Overview
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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
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Overview
Immunohistochemistry of paraffin-embedded mouse brain using HDAC4 antibody (STJ113153) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using HDAC4 antibody (STJ113153) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded rat brain using HDAC4 antibody (STJ113153) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using HDAC4 antibody (STJ113153) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 30s.
Anti-HDAC4 antibody
Anti-HDAC4 antibody
Catalog Number:
A001020511STJ
Mfr. No.:
STJ113153
Price:
$297
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