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Overview
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Ki 67 is a protein encoded by the MKI67 gene which is approximately 358, 6 kDa. Ki 67 is localised to the nucleus. It is involved in DNA damage, neuroscience and primary focal segmental glomerulosclerosis. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. It associates with the surface of the mitotic chromosome and covers a substantial fraction of the chromosome surface. Ki 67 is expressed in the intestine, liver, blood, lung and lymph nodes. Mutations in the MKI67 gene may result in brain ependymoma. STJ96966 was developed from clone 4A8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous Ki 67 proteins.
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Overview