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Overview
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Desmoglein 2 is a member of the desmosomal cadherin family that comprise the desmogleins anddesmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link theintermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domainof desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas theintracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin.Desmoglein 2 is synthesized in the basal layers, depending on the certain types of epidermis.reacts with the 165 kDa desmoglein 2 protein. Furthermore it is not cross reactive withdesmoglein 1 or desmoglein 3. Desmoglein-2 is expressed on various cells including simple epitheliaand myocardium, tumors and and many cell cultures.
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