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Overview
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IL-6 is a protein encoded by the IL6 gene which is approximately 23, 7 kDa. IL-6 is secreted and is involved in apoptotic pathways in synovial fibroblasts, PEDF induced signalling, the GPCR Pathway, the TGF-Beta pathway and toll-like receptor signalling pathways. IL6 is a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor. IL-6 is expressed in the lung, blood, nervous system, bone marrow and the intestines. Mutations in the IL6 gene result in rheumatoid arthritis systemic juvenile and an inflammatory articular disorder. STJ96713 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of IL-6 protein.
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