Name: Anti-Human T-bet antibody
Price: 1999.00 USD

Overview
- T-bet, a T-box transcription factor, is expressed in CD4+ T-lymphocytes committed to T-helper (Th)1 T-cell development from nave T-helper precursor cells (Thp) and redirects Th2 T-cells to Th1development. Anti-T-bet is a marker of mature T-cells and is expressed at very low levels in Thp cellsand is absent in precursor T-lymphoblastic leukemia/lymphoma cells. Scattered small lymphocytes inthe interfollicular T-cell zone of reactive lymphoid tissue, including tonsil, lymph node, and spleenexhibited nuclear staining for anti-T-bet, with no anti-T-bet staining observed in germinal centers ormantle or marginal zones. T-bet is expressed in a significant subset of B-cell lymphoproliferativedisorders, particularly at an early stage of B-cell development (precursor B-cell lymphoblasticleukemia/lymphoblastic lymphoma), and B-cell neoplasms derived from mature B-cells, includingCLL/SLL, marginal zone lymphoma, and hairy cell leukemia.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG1
  
  Reactivity
  
  human
  
  Clone
  
  MRQ-46
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  1 ml supernatant in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
  
  Storage
  
  Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  * For research use only

Applications

Application	Dilutions
IHC	1:100 – 1:500

Anti-Human T-bet antibody