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Overview
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Neuron-specific enolase (NSE) is the glycolytic isoenzyme of the enolase gamma-gamma dimerspecifically detected in neurons of neuroendocrine cells, and their corresponding tumors. In addition, NSE has been demonstrated immunohistochemically in the non-neoplastic cells of the pituitary, peptide secreting tissues, pineolocytes, neuroendocrine cells of the lung, thyroid, parafollicular cells, adrenal medulla, islets of Langerhans, Merkel cells of the skin, and melanocytes. Anti-NSEimmunostaining is also positive in normal striated muscle, hepatocytes and, to a lesser extent, smoothmuscle. Anti-NSE is a useful marker to identify peripheral nerves.5 When used for the identification ofneuroendocrine differentiation, it is suggested that it be employed in a panel with more specificmarkers such as anti-synaptophysin, anti-chromogranin, and anti-neurofilament.
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