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Overview
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Anti-PLAP antibody immunoreacts with germ cell tumors and can discriminate between these andother neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic and urinary cancers mayalso immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with keratin negativityfavors seminoma over carcinoma. Germ cell tumors are usually keratin positive, but they regularly failto stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in thediagnosis of gestational trophoblastic disease. This antibody has shown cross-reaction with humanintestinal alkaline phosphatase.
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