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Overview
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Prostate-Specific Antigen (PSA) is a 33 kDa protein primarily produced by the prostatic epithelium andthe epithelial lining of the periurethral glands. PSA is strongly expressed in both normal and neoplasticprostatic tissue. Although PSA can be considered prostate-specific, PSA and/or PSA gene expressionhas been detected at low levels in some extra-prostatic tissues such as normal breast tissue, breasttumors, endometrium, adrenal neoplasms and renal cell carcinomas. Anti-PSA is most useful indetermining the prostatic origin of carcinomas in non-prostate tissues (metastatic disease) using IHCtechniques. This product is best used in conjunction with a panel of antibodies as, up to 27% ofprostate carcinoma cases (predominantly poorly differentiated carcinomas) can be negative for thismarker.
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Overview