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Overview
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CD33, also known as gp67 or SIGLEC-3, is a 67 kDa glycosylated transmembrane protein that is amember of the sialic acid-binding immunoglobulin-like lectin (siglec) family. Although the precisephysiological function of CD33 is unknown, it may mediate cell to cell adhesion and modulateinflammatory and immune response. In normal tissue, anti-CD33 labels myeloid cells (especiallymyeloid precursors), liver Kupffer cells, lung alveolar macrophages, and placental syncytiotrophoblasts.In neoplastic tissue, anti-CD33 is useful for the identification of acute myeloid leukemia.
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