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Overview
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Cytokeratin 18 is a protein encoded by the KRT18 gene which is approximately 48 kDa. Cytokeratin 18 is localised to the cytoplasm and nucleus. It is involved in development Slit-Robo signalling, cytoskeletal signalling, ERK signalling, developmental biology and keratinization. It plays a role in the uptake of thrombin-antithrombin complexes by hepatic cells and when phosphorylated it plays a role in filament reorganization. It is also involved in the delivery of mutated CFTR to the plasma membrane and together with KRT8, is involved in interleukin-6-mediated barrier protection. Cytokeratin 18 is expressed in the colon, placenta and liver. Mutations in the KRT18 gene may result in cirrhosis. STJ92631 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cytokeratin 18 protein.
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