-
-
Overview
-
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.
Please contact us at for specific academic pricing.
-
- Properties
- Applications
-
Overview
Immunofluorescence analysis of NIH-3T3 cells using GPI antibody (STJ115272) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat brain using GPI antibody (STJ115272) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded rat kidney using GPI antibody (STJ115272) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using GPI antibody (STJ115272) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-GPI antibody
Anti-GPI antibody
Catalog Number:
A001022170STJ
Mfr. No.:
STJ115272
Price:
$297
Size:
Quantity:
Add to Cart:
.