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Overview
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Glycophorins A and B are major sialoglycoproteins expressed across the surface of the humanerythrocyte membrane and contain the antigenic determinants that define the MNS blood groupsystem.1 The high sialic acid content of glycophorin A contributes to the generation of a net negativesurface charge across erythrocyte membranes that minimizes interactions between red blood cellsand prevents their aggregation. Anti-glycophorin A has utility in identifying cells of the erythroidlineage.
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