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Overview
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This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
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- Properties
- Applications
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Overview
Immunofluorescence analysis of mouse brain using GAD2 Rabbit pAb (STJ23739) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded rat brain using GAD2 Antibody (STJ23739) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of rat brain using GAD2 Rabbit pAb (STJ23739) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using GAD2 antibody (STJ23739) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-GAD2 antibody
Anti-GAD2 antibody
Catalog Number:
A001033969STJ
Mfr. No.:
STJ23739
Price:
$297
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