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Overview
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This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
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- Properties
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Overview
Immunofluorescence analysis of U2OS cells using DCTN2 antibody (STJ23348). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human breast cancer using DCTN2 antibody (STJ23348) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human kidney using DCTN2 antibody (STJ23348) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded rat brain using DCTN2 antibody (STJ23348) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of MCF-7 cells, using DCTN2 antibody (STJ23348) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.
Anti-DCTN2 antibody
Anti-DCTN2 antibody
Catalog Number:
A001033738STJ
Mfr. No.:
STJ23348
Price:
$297
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