Anti-DDB1 antibody

Catalog Number:

A001033742STJ

Mfr. No.:

STJ23352

Price:

$297

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Overview
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE)-an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  A synthetic peptide of human DDB1
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Dna Damage-Binding Protein 1; Ddb P127 Subunit; Dna Damage-Binding Protein A; Ddba; Damage-Specific Dna-Binding Protein 1; Hbv X-Associated Protein 1; Xap-1; Uv-Damaged Dna-Binding Factor; Uv-Damaged Dna-Binding Protein 1; Uv-Ddb 1; Xpe-Binding Factor; Xpe-Bf; Xeroderma Pigmentosum Group E-Complementing Protein; Xpce (Gene ID:1642; UniProt:Q16531)
  
  * For research use only