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Overview
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Cytokeratin 6 is a protein encoded by the KRT6B gene which is approximately 60 kDa. Cytokeratin 6 is localised to the cytosol. It is involved in cytoskeletal signalling, developmental biology and keratinization. It consists of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains co-expressed during differentiation of simple and stratified epithelial tissues. Cytokeratin 6 is constitutively expressed in distinct types of epithelial cells such as those in oral mucosa, oesophagus and the hair follicle outer root sheath. Mutations in the KRT6B gene may result in glossitis. STJ96982 was developed from clone 4A1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous Cytokeratin 6 proteins.
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