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Overview
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CK17 is a protein encoded by the KRT17 gene which is approximately 48, 1 kDa. CK17 is localised to the cytoplasm. It is involved in the cytoskeletal signalling, developmental biology, keratinization and the glucocorticoid receptor regulatory network. It is a type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. CK17 is expressed in the outer root sheath and medulla region of hair follicle. Mutations in the KRT17 gene may result in congenital pachyonychia. STJ96983 was developed from clone 10A1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects CK17 endogenous proteins.
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