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Overview
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This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer.
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- Properties
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Overview
Immunofluorescence analysis of HeLa cells using CYP2E1 antibody (STJ23323). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human liver cancer using CYP2E1 antibody (STJ23323) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human stomach using CYP2E1 antibody (STJ23323) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using CYP2E1 antibody (STJ23323) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 10s.
Anti-CYP2E1 antibody
Anti-CYP2E1 antibody
Catalog Number:
A001033724STJ
Mfr. No.:
STJ23323
Price:
$297
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