Anti-CYP3A4 antibody

Catalog Number:

A001033725STJ

Mfr. No.:

STJ23326

Price:

$297

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Overview
- This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, pH7.3.
  
  Storage
  
  Store at 4°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Cytochrome P450 3a4; 1-4-Cineole 2-Exo-Monooxygenase; 1-8-Cineole 2-Exo-Monooxygenase; Albendazole Monooxygenase; Sulfoxide-Forming; Albendazole Sulfoxidase; CypIIIa3; CypIIIa4; Cholesterol 25-Hydroxylase; Cytochrome P450 3a3; Cytochrome P450 Hlp; Cytochrome P450 Nf-25; Cytochrome P450-Pcn1; Nifedipine Oxidase; Quinine 3-Monooxygenase (Gene ID:1576; UniProt:P08684)
  
  * For research use only