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Overview
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Collagen Type IV is the major component of the basal lamina so antibodies to this molecule confirm itspresence and reveal the morphological appearance of the structure. Normal tissue stains with thisantibody in a fashion consistent with the sites of mesenchymal elements and epithelial basal laminae.Anti-Collagen IV can also be useful in the classification of soft tissue tumors; schwannomas, leiomyomas. Their well differentiated, malignant counterparts usually immunoreact with this antibody.The vascular nature of neoplasms, hemangiopericytoma, angiosarcoma and epithelioidhemangioendothelioma can be revealed by this antibody with greater reliability than non-specificstains (e.g. silver reticulum).
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