Name: Anti-CDKN1C antibody
Price: 331.00 USD

Overview
- p57Kip2 (or CDKN1C) is a potent tight‐binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith‐Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin‐like growth factor II (IGF‐II) and H19, both of which seem to be implicated in adrenal neoplasms.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2b kappa
  
  Reactivity
  
  human
  
  Clone
  
  KP10
  
  Immunogen
  
  Recombinant human p57Kip2 protein
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Culture supernatant diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Cyclin-Dependent Kinase Inhibitor 1c; Cyclin-Dependent Kinase Inhibitor P57; P57kip2 (Gene ID:1028; UniProt:P49918)
  
  * For research use only