Anti-Cdk4 antibody

- Overview
  - Mon 1202 recognizes a protein of 34 kDa, identified as cyclin-dependent kinase-4 (cdk4, also known asp34cdk4). CDK4 is a member of the Ser/Thr protein kinase family. This protein is highly similar to thegene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinasecomplex that is important for cell cycle G1 phase progression. The activity of this kinase is restrictedto the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitorp16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma geneproduct (Rb).Immunogen: Purified recombinant cdk4 protein.
    
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- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1
    
    Reactivity
    
    human
    
    Clone
    
    DCS-31
    
    Immunogen
    
    Purified recombinant cdk4 protein.
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    0.5 ml purified antibody in Phosphate Buffer Saline solutioncontaining 0.2% BSA and 0.09% sodium azide.
    
    Storage
    
    Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
    
    Concentration
    
    approximately 0.2 mg/ml
    
    Regulatory Status
    
    RUO
    
    Antigen
    
    Cyclin-Dependent Kinase 4; Cell Division Protein Kinase 4; Psk-J3 (Gene ID:1019; UniProt:P11802)
    
    * For research use only
- Applications
  - Application
    
    IP; WB; Flow Cytometry; IF

Anti-Cdk4 antibody

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