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Overview
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Reacts with the C-terminus of Nucleophosmin (B23). NPM1 (Nucleophosmin 1, B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosomeassembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. NPM1 continuously shuttles between the nucleus, cytoplasm, nucleolus and chaperoning core histones from the nucleus to the cytoplasm. NPM1 hasbeen shown to bind nucleic acid, prevent protein aggregation via its chaperon activities, protectenzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. Inits cellular structure role, there is evidence suggesting NPM1 is associated with the centrosome, andis the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division).Immunogen: NPM/B23 purified from rat hepatoma.
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