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Overview
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CD45RO (an isoform of leukocyte common antigen) is expressed on most thymocytes, monocytes, macrophages and granulocytes. It is not expressed on normal B lymphocytes. Intrathymic T cell maturation progresses from CD45RA‐/CD45RO+ to CD45RA+/CD45RO‐; while peripheral T cell maturation progresses from CD45RA+/CD45RO‐ to CD45RA‐/CD45RO+. UCHL‐1 reacts with mature activated T cells, most thymocytes, and a sub‐population of resting T‐ cells within both CD4 and CD8 subsets. Shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. It rarely stains B cell lymphomas.
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