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Overview
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This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue-and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
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- Properties
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Overview
Immunohistochemistry of paraffin-embedded mouse spleen using CD68 antibody (STJ28637) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human appendix using CD68 antibody (STJ28637) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human tonsil using CD68 antibody (STJ28637) at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human lung using CD68 antibody (STJ28637) at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using CD68 antibody (STJ28637) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 60s.
Anti-CD68 antibody
Anti-CD68 antibody
Catalog Number:
A001036717STJ
Mfr. No.:
STJ28637
Price:
$297
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