Name: Anti-CD33/SIGLE3 antibody
Price: 465.00 USD

- Overview
  - CD33 is a 67 kDa glycoprotein of the sialic acid-binding immunoglobulin-like lectin (SIGLEC) family, displaying the immune-receptor tyrosine-based inhibitory motif (ITIM), able of recruiting proteintyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocyticlineage, binds sialic acid residues in N-and O-glycans on cell surfaces, and is a therapeutic target foracute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoieticstem cells.
    
    Please contact us at for specific academic pricing.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1 kappa
    
    Reactivity
    
    human
    
    Clone
    
    EBS-CD-022
    
    Immunogen
    
    stimulated human AML cells
    
    Conjugate
    
    Unconjugated
    
    Formulation
    
    100 µg affinity purified antibody in Phosphate Buffer Solution containing 0, 02% sodium azide.
    
    Storage
    
    Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
    
    Concentration
    
    100 ug/ml
    
    Regulatory Status
    
    RUO
    
    Antigen
    
    Myeloid Cell Surface Antigen Cd33; Sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; Gp67; Cd Antigen Cd33 (Gene ID:945; UniProt:P20138)
    
    * For research use only
- Applications
  - Application
    
    IHC (frozen); Flow Cytometry; IF
    
    Application Description
    
    IF( 1-2 μg/ml), FC (1-2 μg/million cells in 0.1 ml), IHC Frozen sections (1-2 μg/ml for 30 min at RT)