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Overview
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Reacts with epsilon and delta chain of CD3 complex.T cell activation through the antigenreceptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilonand CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have longcytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association ismediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits.CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen ispresent on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cellsin the cerebellum. It is never expressed on B or NK cells.Immunogen: human thymocytes and T lymphocytes.
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Overview