Anti-CD3 antibody

Anti-CD3 antibody

Catalog Number:
IGA1027836STJ
Mfr. No.:
STJ16100005
Price:
$663
  • Size:
    0.1 mg
    Quantity:
    Add to Cart:
      • Overview
        • Reacts with epsilon and delta chain of CD3 complex.T cell activation through the antigenreceptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilonand CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have longcytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association ismediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits.CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen ispresent on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cellsin the cerebellum. It is never expressed on B or NK cells.Immunogen: human thymocytes and T lymphocytes.

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      • Properties
        • Host
          mouse
          Antibody Type
          monoclonal
          Isotype
          IgG2a
          Reactivity
          human
          Clone
          MEM-57
          Immunogen
          Human thymocytes and T lymphocytes
          Conjugate
          Unconjugated
          Formulation
          100 µg purified antibody in PBS containing 15 mM sodium aside, pH 7.41mg/ml
          Storage
          Store antibody at 2-8°C until expiry date. Minimise freeze-thaw cycles.
          Concentration
          1mg/ml
          Regulatory Status
          RUO

          * For research use only

      • Applications
        • Application
          IP; Flow Cytometry

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