Anti-CD3 antibody

- Overview
  - Reacts with epsilon and delta chain of CD3 complex.T cell activation through the antigenreceptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilonand CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins superfamily encoded by closely linked genes on human chromosome 11. The CD3 components have longcytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association ismediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits.CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen ispresent on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cellsin the cerebellum. It is never expressed on B or NK cells.Immunogen: human thymocytes and T lymphocytes.
    
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- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG2a
    
    Reactivity
    
    human
    
    Clone
    
    MEM-57
    
    Immunogen
    
    Human thymocytes and T lymphocytes
    
    Conjugate
    
    PE
    
    Formulation
    
    2 ml purified antibody, conjugated with R-Phycoerythrin in PBS containing 15 mM sodium Azide, pH 7.4. Suitable for 100 tests.
    
    Storage
    
    Store antibody at 2-8°C until expiry. Avoid prolonged exposure to light.
    
    Concentration
    
    1 mg/ml
    
    Regulatory Status
    
    RUO
    
    * For research use only
- Applications
  - Application
    
    Flow Cytometry
    
    Application Description
    
    FC; analysis of human blood cells using 20 µl reagent/100 µlwhole blood.

Anti-CD3 antibody

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