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Overview
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Reacts with CD22, a 130 kDa type Itransmembrane glycoprotein (immunoglobulinsuperfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of matureand activated B lymphocytes. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a threshold for Bcell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controllingthe CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22exhibits hallmarks of clathrin-mediated endocytic pathway.Immunogen: Raji Burkitt's lymphoma cell line
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