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Overview
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The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e. g., RUNX1) and osteogenesis (e. g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
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Overview
Immunofluorescence analysis of U2OS cells using CBFB antibody (STJ27258). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human kidney cancer using CBFB Antibody (STJ27258) at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded mouse brain using CBFB Antibody (STJ27258) at dilution of 1:200 (40x lens).
Western blot analysis of extracts of various cell lines, using CBFB antibody (STJ27258) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit._Exposure time: 90s.
Anti-CBFB antibody
Anti-CBFB antibody
Catalog Number:
A001035731STJ
Mfr. No.:
STJ27258
Price:
$297
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