Anti-CASP9 antibody

Catalog Number:

A001020508STJ

Mfr. No.:

STJ113147

Price:

$297

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Overview
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.
  
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Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CASP9 (NP_001220. 2).
  
  Purification
  
  Affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  
  Storage
  
  Store at -20°C and avoid freeze-thaw cycles.
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Caspase-9; Casp-9; Apoptotic Protease Mch-6; Apoptotic Protease-Activating Factor 3; Apaf-3; Ice-Like Apoptotic Protease 6; Ice-Lap6 Cleaved Into-Caspase-9 Subunit P35-Caspase-9 Subunit P10 (Gene ID:842; UniProt:P55211)
  
  * For research use only