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Overview
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The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero-or homodimers and act as anti-or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
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Overview
Immunohistochemistry of paraffin-embedded human liver using BCL2L11 antibody (STJ114428) at dilution of 1:100 (40x lens).
Immunofluorescence analysis of HeLa cells using BCL2L11 antibody (STJ114428). Blue: DAPI for nuclear staining.
Immunohistochemistry of paraffin-embedded human tonsil using BCL2L11 antibody (STJ114428) at dilution of 1:100 (40x lens).
Anti-BCL2L11 antibody
Anti-BCL2L11 antibody
Catalog Number:
A001021391STJ
Mfr. No.:
STJ114428
Price:
$297
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